Tramadol, an opioid analgesic, is not routinely screened for in standard drug tests. This is because typical panels focus on more commonly abused opioids like heroin, morphine, codeine, oxycodone, and hydrocodone. Therefore, a general drug screening, such as those used for employment or probation, will typically not detect tramadol. If specific detection is required, a specialized assay must be requested.
The need for specialized testing arises from tramadols unique metabolic pathway and its increasing prevalence as a prescribed pain reliever. While it has a lower risk of respiratory depression compared to other opioids, tramadol still carries a potential for abuse and dependence. Furthermore, individuals might be taking tramadol legitimately under prescription, necessitating a distinction between prescribed use and potential misuse or diversion. Historically, its initial classification as a non-narcotic analgesic led to less stringent monitoring, which has since evolved with increasing awareness of its opioid-like effects.